RAMB - JULHO 2017

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Mild cognitive impairment and progression to dementia of Alzheimer’s disease
Rev Assoc Med B ras 2017; 63(7):651-655 653
FIGURE 1 Current algorithm used to classify the subtypes of mild cognitive impairment (MCI).
Source: Petersen R.13
FIGURE 2 Charting the Course from Healthy Ageing to AD.
MCI: mild cognitive impairment; AD: Alzheimer’s disease.
Source: National Institute On Aging – NIH.
Yes
Yes Yes
No
No No
Mild cognitive impairment
Cognitive complaint
MCI
Memory impaired?
Amnestic MCI Non-amnestic MCI
Memory impairment
only?
Amnestic MCI
Single Domain
Amnestic MCI
Multiple Domains
Non-amnestic MCI
Single Domain
Non-amnestic MCI
Multiple Domain
Single non-memory
cognitive domain impaired?
Not normal for age
Not demented
Cognitive decline
Essentially normal functional activities
Birth Death
Life course
Healthy aging Amnestic MCI Clinically diagnosed AD
AD brain
changes start
decades before
symptoms show
Cognitive
decline
accelerates
after AD
diagnosis
Total loss of
independent
function
Normal age-related
memory loss
Amnestic MCI:
memory problems;
other cognitive
functions OK; brain
compensates for
changes
40 60 80