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E
ffect
of
fluoride
on
salivary
immunoglobulins
and
sialic
acid
R
ev
A
ssoc
M
ed
B
ras
2017; 63(4):320-323
323
from babies including level of sialic acid, which was re-
duced as the children aged.
Salivary sialic acid levels were compared with those
of children with systemic problems. Two studies found
that salivary sialic acid levels were higher in healthy indi-
viduals than in children with Down syndrome.
8,23
How-
ever, this difference was significant in only one of the two
studies. Similarly, the salivary sialic acid level was found
to be higher in a control group than in diabetic children.
24
Patients with cystic fibrosis have been shown to have
significantly lower sialic acid concentrations compared
with a control group.
25
These differences in sialic acid
level have been interpreted as influenced more by the ef-
fects of systemic diseases than by local factors.
8
C
onclusion
In our study, gathering a large group of children using
the same parameters to standardize was quite difficult.
We conclude that sIgA and sIgG levels were higher in
children with dental fluorosis than in those with healthy
teeth, even though the difference was not significant.
Therefore, increased levels of sIgA and IgG in dental flu-
orosis may arrest the progression of dental caries. Given
the risks of dental fluorosis, further studies of the effects
of different fluoride levels in drinking water on salivary
characteristics are needed to confirm the results of our
study and to provide data for comparison. Studies con-
ducted in samples with features similar to those of our
study will increase the knowledge available.
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