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PSA

screening

for

prostate

cancer

R

ev

A

ssoc

M

ed

B

ras

2017; 63(8):722-725

725

R

esumo

Rastreamento do câncer de próstata com PSA

O rastreamento do câncer de próstata com antígeno pros-

tático específico (PSA) é uma questão altamente contro-

versa. Parte da polêmica se deve à confusão entre rastrea-

mento populacional e diagnóstico precoce, e outra parte

está ligada a problemas relacionados à qualidade dos

estudos de rastreamento recentes, a resultados do trata-

mento curativo radical para tumores de baixo grau ou em

estágio precoce, e a complicações advindas de tratamen-

tos que afetam a qualidade de vida do paciente. Nossa

revisão teve como objetivo analisar criticamente as reco-

mendações atuais para o teste de PSA, com base em dados

obtidos da reavaliação de estudos em andamento e na

recomendação atualizada do USPSTF, e propor o uso

mais racional e seletivo do PSA comparado a níveis iniciais

obtidos em uma idade aproximada de 40 a 50 anos.

Palavras-chave:

PSA, câncer de próstata, rastreamento,

próstata.

R

eferences

1.

INCA. Tipos de câncer. Próstata [cited 2017 Jul 18]. Available from: http://

www2.inca.gov.br/wps/wcm/connect/tiposdecancer/site/home/prostata.

2.

Bell KJ, Del Mar C, Wright G, Dickinson J, Glasziou P. Prevalence of incidental

prostate cancer: a systematic review of autopsy studies. Int J Cancer. 2015;

137(7):1749-57.

3.

Epstein JI, Egevad L, Amin MB, Delahunt B, Srigley JR, Humphrey PA;

Grading Committee. The 2014 International Society of Urological Pathology

(ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma:

definition of grading patterns and proposal for a new grading system. Am

J Surg Pathol. 2016; 40(2):244-52.

4. Cooperberg MR, Lubeck DP, Mehta SS, Carroll PR; CaPSURE. Time trends

in clinical risk stratification for prostate cancer: implications for outcomes

(data from CaPSURE). J Urol. 2003; 170(6 Pt 2):S21-5.

5. Welch HG, Gorski DH, Albertsen PC. Trends in metastatic breast and prostate

cancer: Lessons in cancer dynamics. N Engl J Med. 2015; 373(18):1685-7.

6.

Labrie F, Candas B, Dupont A, Cusan L, Gomez JL, Suburu RE, et al. Screening

decreases prostate cancer death: first analysis of the 1988 Quebec prospective

randomized controlled trial. Prostate. 1999; 38(2):83-91.

7.

Sandblom G, Varenhorst E, Löfman O, Rosell J, Carlsson P. Clinical

consequences of screening for prostate cancer: 15 years follow-up of a

randomised controlled trial in Sweden. Eur Urol. 2004; 46(6):717-23.

8.

Ilic D, O’Connor D, Green S, Wilt T. Screening for prostate cancer: a Cochrane

systematic review. Cancer Causes Control. 2007; 18(3):279-85.

9.

Schröder FH, Hugosson J, Roobol MJ, Tammela TL, Ciatto S, Nelen V, et

al.; ERSPC Investigators. Prostate-cancer mortality at 11 years of follow-

up. N Engl J Med. 2012; 366(11):981-90.

10.

Roobol MJ, Kranse R, Bangma CH, van Leenders AG, Blijenberg BG, van

Schaik RH, et al.; ERSPC Rotterdam Study Group. Screening for prostate

cancer: results of the Rotterdam section of the European randomized study

of screening for prostate cancer. Eur Urol. 2013; 64(4):530-9.

11. Andriole GL, Crawford ED, Grubb RL 3rd, Buys SS, Chia D, Church TR, et

al.; PLCO Project Team. Mortality results from a randomized prostate-

cancer screening trial. N Engl J Med. 2009; 360(13):1310-9.

12.

Hugosson J, Carlsson S, Aus G, Bergdahl S, Khatami A, Lodding P, et al.

Mortality results from the Göteborg randomised population-based prostate-

cancer screening trial. Lancet Oncol. 2010; 11(8):725-32.

13.

Moyer VA; U.S. Preventive Services Task Force. Screening for prostate cancer:

U.S. Preventive Services Task Force recommendation statement. Ann Intern

Med. 2012; 157(2):120-34.

14. Wilt TJ, Jones KM, Barry MJ, Andriole GL, Culkin D, Wheeler T, Aronson

WJ, Brawer MK. Follow-up of prostatectomy versus observation for early

prostate cancer. N Engl J Med. 2017; 377(2):132-142.

15. Thompson IM, Pauler DK, Goodman PJ, Tangen CM, Lucia MS, Parnes HL,

et al. Prevalence of prostate cancer among men with a prostate-specific anti-

gen level < or =4.0 ng per milliliter. N Engl J Med. 2004; 350(22):2239-46.

16. Carter HB, Albertsen PC, Barry MJ, Etzioni R, Freedland SJ, Greene KL, et al.

Early detection of prostate cancer: AUA Guideline. J Urol. 2013; 190(2):419-26.

17. Vickers AJ, Ulmert D, Sjoberg DD, Bennette CJ, Björk T, Gerdtsson A, et al.

Strategy for detection of prostate cancer based on relation between prostate

specific antigen at age 40-55 and long term risk of metastasis: case-control

study. BMJ. 2013; 346:f2023.

18. Bibbins-Domingo K, Grossman DC, Curry SJ. The US Preventive Services

Task Force 2017 draft recommendation statement on screening for prostate

cancer: an invitation to review and comment. JAMA. 2017; 317(19):1949-50.

19.

Hamdy FC, Donovan JL, Lane JA, Mason M, Metcalfe C, Holding P, et

al.; ProtecT Study Group. 10-year outcomes after monitoring, surgery,

or radiotherapy for localized prostate cancer. N Engl J Med. 2016;

375(15):1415-24.

20.

Sociedade Brasileira de Urologia. NOTA OFICIAL – Rastreamento do Câncer

de Próstata. 2016 [cited 2017 Jul 18]. Available from: http://portaldaurologia.

org.br/noticias/nota-oficial-rastreamento-do-cancer-de-prostata-2/.