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S

imões

and

B

ernardo

6

R

ev

A

ssoc

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ed

B

ras

2017; 63(1):4-6

examination of euploid fetuses due to increased nuchal

translucency.

11

(

D

) In this regard, the findings of the re-

lated studies do not reflect the true performance of first-

-trimester ultrasonography for the screening of nonchro-

mosomal abnormalities. A multicenter clinical trial

conducted by Saltvedt et al. was designed to analyze the

sensitivity of morphological ultrasound examinations

performed during the first and second trimesters to iden-

tify fetal malformations. To do so, they randomized more

than 39,000 pregnant women to perform a single ultra-

sound during pregnancy, between weeks 12 and 14, or

between weeks 15 and 22. The authors found a detection

rate of 38% for the first group compared to 47% for the

second, but the difference was not significant.

12

(

B

)

R

ecommendation

Routine ultrasonography performed in the first trimester

of low-risk pregnancies allows a better calculation of ges-

tational age, preventing diagnosis of a later due date and

consequent iatrogenic preterm delivery. It also allows the

characterization of the number of fetuses and chorionic-

ity.

13

(

A

). This imaging modality also contributes to the

identification of aneuploidy and, increasingly, to the di-

agnosis of structural anomalies.

R

eferences

1.

BRASIL. Ministério da Saúde. Atenção ao pré-natal de baixo risco. Brasília:

Ministério da Saúde, 2012. (Cadernos de Atenção Básica, 32)

2.

Savitz DA, Terry JW Jr, Dole N, Thorp JM Jr, Siega-Riz AM, Herring AH.

Comparison of pregnancy dating by last menstrual period, ultrasound scanning,

and their combination. Am J Obstet Gynecol. 2002; 187(6):1660-6.

3. HoffmanCS,MesserLC,MendolaP,SavitzDA,HerringAH

,HartmannKE.Com

-

parisonofgestationalage at birth based on last menstrual period and ultrasound

during the first trimester. Paediatr Perinat Epidemiol. 2008; 22(6):587-96.

4. Taipale P, Hiilesmaa V. Predicting delivery date by ultrasound and last

menstrual period in early gestation. Obstet Gynecol. 2001; 97(2):189-94.

5. Nguyen TH, Larsen T, Engholm G, Møller H. Evaluation of ultrasound-

estimated date of delivery in 17,450 spontaneous singleton births: do we need

to modify Naegele’s rule? Ultrasound Obstet Gynecol. 1999; 14(1):23-8.

6. Tunón K, Eik-Nes SH, Grøttum P. A comparison between ultrasound and

a reliable last menstrual period as predictors of the day of delivery in 15,000

examinations. Ultrasound Obstet Gynecol. 1996; 8(3):178-85.

7.

Lee YM, Cleary-Goldman J, Thaker HM, Simpson LL. Antenatal sonographic

prediction of twin chorionicity. Am J Obstet Gynecol. 2006; 195(3):863-7.

8.

Menon DK. A retrospective study of the accuracy of sonographic chorionicity

determination in twin pregnancies. Twin Res HumGenet. 2005; 8(3):259-61.

9.

Kagan KO, Wright D, Valencia C, Maiz N, Nicolaides KH. Screening for

trisomies 21, 18 and 13 by maternal age, fetal nuchal translucency, fetal

heart rate, free beta-hCG and pregnancy-associated plasma protein-A. Hum

Reprod. 2008; 23(9):1968-75.

10.

Souka AP, Snijders RJ, Novakov A, Soares W, Nicolaides KH. Defects and

syndromes in chromosomally normal fetuses with increased nuchal

translucency thickness at 10-14 weeks of gestation. Ultrasound Obstet

Gynecol. 1998; 11(6):391-400.

11.

Souka AP, Von Kaisenberg CS, Hyett JA, Sonek JD, Nicolaides KH. Increased

nuchal translucency with normal karyotype. Am J Obstet Gynecol. 2005;

192(4):1005-21.

12.

Saltvedt S, Almström H, Kublickas M, Valentin L, Grunewald C. Detection

of malformations in chromosomally normal fetuses by routine ultrasound

at 12 or 18 weeks of gestation - a randomised controlled trial in 39,572

pregnancies. BJOG. 2006; 113(6):664-74.

13. Whitworth M, Bricker L, Mullan C. Ultrasound for fetal assessment in early

pregnancy. Cochrane Database Syst Rev. 2015; (7):CD007058.