S
imões
and
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ernardo
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ev
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ssoc
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ed
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ras
2017; 63(1):4-6
examination of euploid fetuses due to increased nuchal
translucency.
11
(
D
) In this regard, the findings of the re-
lated studies do not reflect the true performance of first-
-trimester ultrasonography for the screening of nonchro-
mosomal abnormalities. A multicenter clinical trial
conducted by Saltvedt et al. was designed to analyze the
sensitivity of morphological ultrasound examinations
performed during the first and second trimesters to iden-
tify fetal malformations. To do so, they randomized more
than 39,000 pregnant women to perform a single ultra-
sound during pregnancy, between weeks 12 and 14, or
between weeks 15 and 22. The authors found a detection
rate of 38% for the first group compared to 47% for the
second, but the difference was not significant.
12
(
B
)
R
ecommendation
Routine ultrasonography performed in the first trimester
of low-risk pregnancies allows a better calculation of ges-
tational age, preventing diagnosis of a later due date and
consequent iatrogenic preterm delivery. It also allows the
characterization of the number of fetuses and chorionic-
ity.
13
(
A
). This imaging modality also contributes to the
identification of aneuploidy and, increasingly, to the di-
agnosis of structural anomalies.
R
eferences
1.
BRASIL. Ministério da Saúde. Atenção ao pré-natal de baixo risco. Brasília:
Ministério da Saúde, 2012. (Cadernos de Atenção Básica, 32)
2.
Savitz DA, Terry JW Jr, Dole N, Thorp JM Jr, Siega-Riz AM, Herring AH.
Comparison of pregnancy dating by last menstrual period, ultrasound scanning,
and their combination. Am J Obstet Gynecol. 2002; 187(6):1660-6.
3. HoffmanCS,MesserLC,MendolaP,SavitzDA,HerringAH
,HartmannKE.Com-
parisonofgestationalage at birth based on last menstrual period and ultrasound
during the first trimester. Paediatr Perinat Epidemiol. 2008; 22(6):587-96.
4. Taipale P, Hiilesmaa V. Predicting delivery date by ultrasound and last
menstrual period in early gestation. Obstet Gynecol. 2001; 97(2):189-94.
5. Nguyen TH, Larsen T, Engholm G, Møller H. Evaluation of ultrasound-
estimated date of delivery in 17,450 spontaneous singleton births: do we need
to modify Naegele’s rule? Ultrasound Obstet Gynecol. 1999; 14(1):23-8.
6. Tunón K, Eik-Nes SH, Grøttum P. A comparison between ultrasound and
a reliable last menstrual period as predictors of the day of delivery in 15,000
examinations. Ultrasound Obstet Gynecol. 1996; 8(3):178-85.
7.
Lee YM, Cleary-Goldman J, Thaker HM, Simpson LL. Antenatal sonographic
prediction of twin chorionicity. Am J Obstet Gynecol. 2006; 195(3):863-7.
8.
Menon DK. A retrospective study of the accuracy of sonographic chorionicity
determination in twin pregnancies. Twin Res HumGenet. 2005; 8(3):259-61.
9.
Kagan KO, Wright D, Valencia C, Maiz N, Nicolaides KH. Screening for
trisomies 21, 18 and 13 by maternal age, fetal nuchal translucency, fetal
heart rate, free beta-hCG and pregnancy-associated plasma protein-A. Hum
Reprod. 2008; 23(9):1968-75.
10.
Souka AP, Snijders RJ, Novakov A, Soares W, Nicolaides KH. Defects and
syndromes in chromosomally normal fetuses with increased nuchal
translucency thickness at 10-14 weeks of gestation. Ultrasound Obstet
Gynecol. 1998; 11(6):391-400.
11.
Souka AP, Von Kaisenberg CS, Hyett JA, Sonek JD, Nicolaides KH. Increased
nuchal translucency with normal karyotype. Am J Obstet Gynecol. 2005;
192(4):1005-21.
12.
Saltvedt S, Almström H, Kublickas M, Valentin L, Grunewald C. Detection
of malformations in chromosomally normal fetuses by routine ultrasound
at 12 or 18 weeks of gestation - a randomised controlled trial in 39,572
pregnancies. BJOG. 2006; 113(6):664-74.
13. Whitworth M, Bricker L, Mullan C. Ultrasound for fetal assessment in early
pregnancy. Cochrane Database Syst Rev. 2015; (7):CD007058.