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et
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.
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2017; 63(2):180-189
7.
Patel M, Yang S. Advances in reprogramming somatic cells to induced
pluripotent stem cells. Stem Cell Rev. 2010; 6(3):367-80.
8.
Johnson MH, Cohen J. Reprogramming rewarded: the 2012 Nobel Prize for
Physiology or Medicine awarded to John Gurdon and Shinya Yamanaka.
Reprod Biomed Online. 2012; 25(6):549-50.
9.
Lowry WE, Plath K. The many ways to make an iPS cell. Nat Biotechnol.
2008; 26(11):1246-8.
10. Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, Tian
S, et al. Induced pluripotent stem cell lines derived from human somatic
cells. Science. 2007; 318(5858):1917-20.
11. Takahashi K, Yamanaka S. Induced pluripotent stem cells in medicine and
biology. Development. 2013; 140(12):2457-61.
12. Apostolou E, Hochedlinger K. Chromatin dynamics during cellular
reprogramming. Nature. 2013; 502(7472):462-71.
13. Chin MH, Mason MJ, Xie W, Volinia S, Singer M, Peterson C, et al. Induced
pluripotent stem cells and embryonic stem cells are distinguished by gene
expression signatures. Cell Stem Cell. 2009; 5(1):111-23.
14.
Kim K, Doi A, Wen B, Ng K, Zhao R, Cahan P, et al. Epigenetic memory in
induced pluripotent stem cells. Nature. 2010; 467(7313):285-90.
15.
Polo JJM, Liu S, Figueroa MME, Kulalert W, Eminli S, Tan KY, et al. Cell
type of origin influences the molecular and functional properties of mouse
induced pluripotent stem cells. Nat Biotechnol. 2010; 28(8):848-55.
16.
Nashun B, Hill PWS, Hajkova P. Reprogramming of cell fate: epigenetic
memory and the erasure of memories past. EMBO J. 2015; 34(10):1296-308.
17. Waddington CH. The epigenotype. 1942. Int J Epidemiol. 2012; 41(1):10-3.
18.
Haig D. The (dual) origin of epigenetics. Cold Spring Harb Symp Quant
Biol. 2004; 69:67-70.
19.
Kim SY, Morales CR, Gillette TG, Hill JA. Epigenetic regulation in heart
failure. Curr Opin Cardiol. 2016; 31(3):255-65.
20. Abdolmaleky HM, Zhou J-R, Thiagalingam S. An update on the epigenetics
of psychotic diseases and autism. Epigenomics. 2015; 7(3):427-49.
21.
Faroogi AA, Tang JY, Li RN, Ismail M, Chang YT, Shu CW, et al. Epigenetic
mechanisms in cancer: push and pull between kneaded erasers and fate
writers. Int J Nanomedicine. 2015; 10:3183-91.
22. Coppedè F. The potential of epigenetic therapies in neurodegenerative
diseases. Front Genet. 2014; 5:220.
23. Gładych M, Andrzejewska A, Oleksiewicz U, Estécio MRH. Epigenetic
mechanisms of induced pluripotency. Contemp Oncol (Pozn). 2015;
19(1A):A30-8.
24.
Djuric U, Ellis J. Epigenetics of induced pluripotency, the seven-headed
dragon. Stem Cell Res Ther. 2010; 1(1):3.
25.
Liang G, Zhang Y. Embryonic stem cell and induced pluripotent stem cell:
an epigenetic perspective. Cell Res. 2013; 23(1):49-69.
26.
Hackett JA, Surani MA. DNA methylation dynamics during the mammalian
life cycle. Philos Trans R Soc Lond B Biol Sci. 2013; 368(1609):20110328.
27.
Nishino K, Toyoda M, Yamazaki-Inoue M, Fukawatase Y, Chikazawa E,
Sakaguchi H, et al. DNA methylation dynamics in human induced pluripotent
stem cells over time. PLoS Genet. 2011; 7(5):5-8.
28.
Popp C, Dean W, Feng S, Cokus SJ, Andrews S, Pellegrini M, et al. Genome-
wide erasure of DNA methylation in mouse primordial germ cells is affected
by AID deficiency. Nature. 2010; 463(7284):1101-5.
29.
Doege CA, Inoue K, Yamashita T, Rhee DB, Travis S, Fujita R, et al. Early-
-stage epigenetic modification during somatic cell reprogramming by Parp1
and Tet2. Nature. 2012; 488(7413):652-5.
30. Costa Y, Ding J, Theunissen TW, Faiola F, Hore TA, Shliaha PV, et al. NANOG-
-dependent function of TET1 and TET2 in establishment of pluripotency. Na-
ture. 2013; 495(7441):370-4.
31. Gao Y, Chen J, Li K, Wu T, Huang B, LiuW, et al. Replacement of Oct4 by Tet1
during iPSC induction reveals an important role of DNA methylation and
hydroxymethylation in reprogramming. Cell Stem Cell. 2013; 12(4):453-69.
32. Watanabe A, Yamada Y, Yamanaka S. Epigenetic regulation in pluripotent
stem cells: a key to breaking the epigenetic barrier. Phil Trans R Soc. 2013;
368:(1609):20120292.
33.
Mikkelsen TS, Hanna J, Zhang X, Ku M, Wernig M, Schorderet P, et al.
Dissecting direct reprogramming through integrative genomic analysis.
Nature. 2008; 454(7200):49-55.
34. Wang T, Chen K, Zeng X, Yang J, Wu Y, Shi X, et al. The histone demethylases
Jhdm1a/1b enhance somatic cell reprogramming in a vitamin-C-dependent
manner. Cell Stem Cell. 2011; 9(6):575-87.
35.
Esteban MA, Wang T, Qin B, Yang J, Qin D, Cai J, et al. Vitamin C enhances
the generation of mouse and human induced pluripotent stem cells. Cell
Stem Cell. 2010; 6(1):71-9.
36.
Bagci H, Fisher AG. DNA demethylation in pluripotency and reprogramming:
the role of Tet proteins and cell division. Cell Stem Cell. 2013; 13(3):265-9.
37.
Sadakierska-Chudy A, Filip M. A comprehensive view of the epigenetic
landscape. Part II: Histone post-translational modification, nucleosome level,
and chromatin regulation by ncRNAs. Neurotox Res. 2014; 27(2):172-97.
38.
Eissenberg JC, Shilatifard A. Histone H3 lysine 4 (H3K4) methylation in
development and differentiation. Dev Biol. 2010; 339(2):240-9.
39.
Becker JS, Nicetto D, Zaret KS. H3K9me3-dependent heterochromatin:
barrier to cell fate changes. Trends Genet. 2016; 32(1):29-41.
40.
Lin T, Wu S. Reprogramming with small molecules instead of exogenous
transcription factors. Stem Cells Int. 2015; 2015:794632.
41.
Rais Y, Zviran A, Geula S, Gafni O, Chomsky E, Viukov S, et al. Deterministic
direct reprogramming of somatic cells to pluripotency. Nature. 2013;
502(7469):65-70.
42.
Hou P, Li Y, Zhang X, Liu C, Guan J, Li H, et al. Pluripotent stem cells induced
from mouse somatic cells by small-molecule compounds. Science. 2013;
341(6146):651-4.
43.
Shi Y, Desponts C, Do JT, Hahm HS, Schöler HR, Ding S. Induction of
pluripotent stem cells frommouse embryonic fibroblasts by Oct4 and Klf4
with small-molecule compounds. Cell Stem Cell. 2008; 3(5):568-74.
44.
Huangfu D, Maehr R, Guo W, Eijkelenboom A, Snitow M, Chen AE, et al.
Induction of pluripotent stem cells by defined factors is greatly improved
by small-molecule compounds. Nat Biotechnol. 2008; 26(7):795-7.
45. Chen J, Liu H, Liu J, Qi J, Wei B, Yang J, et al. H3K9 methylation is a barrier
during somatic cell reprogramming into iPSCs. Nat Genet. 2013; 45(1):34-42.
46.
Liang G, Taranova O, Xia K, Zhang Y. Butyrate promotes induced pluripotent
stem cell generation. J Biol Chem. 2010; 285(33):25516-21.
47.
Onder TT, Kara N, Cherry A, Sinha AU, Zhu N, Bernt KM, et al. Chromatin-
-modifying enzymes as modulators of reprogramming. Nature. 2012;
483(7391):598-602.
48.
Liang G, He J, Zhang Y. Kdm2b promotes induced pluripotent stem cell
generation by facilitating gene activation early in reprogramming. Nat Cell
Biol. 2012; 14(5):457-66.
49.
Zare M, Soleimani M, Akbarzadeh A, Bakhshandeh B, Aghaee-Bakhtiari SH,
Zarghami N. A novel protocol to differentiate induced pluripotent stem
cells by neuronal microRNAs to provide a suitable cellular model. Chem
Biol Drug Des. 2015; 86(2):232-8.
50.
Li MA, He L. microRNAs as novel regulators of stem cell pluripotency and
somatic cell reprogramming. Bioessays. 2012; 34(8):670-80.
51. Wang Y, Medvid R, Melton C, Jaenisch R, Blelloch R. DGCR8 is essential
for microRNA biogenesis and silencing of embryonic stem cell self-renewal.
Nat Genet. 2007; 39(3):380-5.
52. Wang Y, Baskerville S, Shenoy A, Babiarz JE, Baehner L, Blelloch R. Embryonic
stem cell-specific microRNAs regulate the G1-S transition and promote
rapid proliferation. Nat Genet. 2008; 40(12):1478-83.
53.
He L, Hannon GJ. MicroRNAs: small RNAs with a big role in gene regulation.
Nat Rev Genet. 2004; 5(7):522-31.
54.
Judson RL, Babiarz JE, Venere M, Blelloch R. Embryonic stem cell-specific
microRNAs promote induced pluripotency. Nat Biotechnol. 2009; 27(5):459-61.
55.
Subramanyam D, Lamouille S, Judson RL, Liu JY, Bucay N, Derynck R, et
al. Multiple targets of miR-302 and miR-372 promote reprogramming of
human fibroblasts to induced pluripotent stem cells. Nat Biotechnol. 2011;
29(5):443-8.
56.
Lin SL, Chang DC, Lin CH, Ying SY, Leu D, Wu DTS. Regulation of somatic
cell reprogramming through inducible mir-302 expression. Nucleic Acids
Res. 2011; 39(3):1054-65.
57. Anokye-Danso F, Trivedi CM, Juhr D, Gupta M, Cui Z, Tian Y, et al. Highly
efficient miRNA-mediated reprogramming of mouse and human somatic
cells to pluripotency. Cell Stem Cell. 2011; 8(4):376-88.
58.
Hu S, Wilson KD, Ghosh Z, Han L, Wang Y, Lan F, et al. MicroRNA-302
increases reprogramming efficiency via repression of NR2F2. Stem Cells.
2013; 31(2):259-68.
59.
Samavarchi-Tehrani P, Golipour A, David L, Sung HK, Beyer TA, Datti A,
et al. Functional genomics reveals a BMP-driven mesenchymal-to-epithelial
transition in the initiation of somatic cell reprogramming. Cell Stem Cell.
2010; 7(1):64-77.
60.
Li Z, Yang C, Nakashima K, Rana TM. Small RNA-mediated regulation of
iPS cell generation. EMBO J. 2011; 30(5):823-34.
61.
Li Z, Dang J, Chang K, Rana TM. MicroRNA-mediated regulation of
extracellular matrix formation modulates somatic cell reprogramming. RNA.
2014; 20(12):1900-15.