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B
arros
-O
liveira
MC
et
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.
374
R
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2017; 63(4):371-378
Exemestane
Anastrozole
Letrozole
Steroidal aromatase inactivator
Nonsteroidal aromatase inhibitors
CH
2
CH
3
CH
3
CN
CN
NC
NC
H
3
C
H
3
C
A
B
O
O
N
N
N
N
N
N
Androstenedione
Testosterone
Estrone
Estradiol
Aromatase
inhibitor
Aromatase
inhibitor
Aromatase
Aromatase
FIGURE 3
Chemical structures of currently used antiaromatase compounds. A. Steroidal aromatase inactivator. B. Nonsteroidal
aromatase inhibitors.
Source: adapted from Geisler and Lønning.
7
FIGURE 4
Mechanism of action of aromatase inhibitors.
Source: adapted from Johnston and Dowsett.
18