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B
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-O
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MC
et
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372
R
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A
ssoc
M
ed
B
ras
2017; 63(4):371-378
Hypothalamus
Ovary
Estrogens
Estrogens
Androgens
Adrenal gland
Adipose
Bone
Breast
Liver
Postmenopausal
Premenopausal
Aromatase
Aromatase
Hypophysis
Androgens
Adrenocorticotropic
hormone (ACTH)
Gonadotropins
(LH + FSH)
FIGURE 1
Estrogen production in premenopausal and postmenopausal women.
LH: luteinizing hormone; FSH: follicle-stimulating hormone.
Source: adapted from Freedman et al.
6
FIGURE 2
Molecular structure of the androgen substrates of aromatase and the corresponding estrogen products.
Source: adapted from Di Nardo and Gilardi.
8
Testosterone
Estradiol
Estrone
Estriol
Androstenedione
16-
α
-hydroxytestosterone
CH
3
CH
3
CH
3
CH
3
CH
3
CH
3
CH
3
CH
3
CH
3
OH
HO
HO
HO
OH
OH
OH
OH
OH
O
O
O
O
O