M
icro
RNA
s
,
cancer
and
ionizing
radiation
: W
here
are
we
?
R
ev
A
ssoc
M
ed
B
ras
2015; 61(3):275-281
281
43.
Deng S, Calin GA, Croce CM, Coukos G, Zhang L. Mechanisms of microRNA
deregulation in human cancer. Cell Cycle. 2008; 7(17):2643-6.
44.
Bussing I, Slack FJ, Grosshans H. Let-7 microRNAs in development, stem
cells and cancer. Trends Mol Med. 2008; 14(9):400-9.
45.
Johnson SM, Grosshans H, Shingara J, Byrom M, Jarvis R, Cheng A, et al.
RAS is regulated by the let-7 microRNA family. Cell. 2005; 120(5):635-47.
46.
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S. MAPK pathways in
radiation responses. Oncogene. 2003; 22(37):5885-96.
47.
Simone NL, Soule BP, Ly D, Saleh AD, Savage JE, Degraff W, et al. Ionizing
radiation-induced oxidative stress alters miRNA expression. PLoS One. 2009;
4(7):e6377.
48. Tarasov V, Jung P, Verdoodt B, Lodygin D, Epanchintsev A, Menssen A, et
al. Differential regulation of microRNAs by p53 revealed by massively parallel
sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest.
Cell Cycle. 2007; 6(13):1586-93.
49.
Koturbash I, Zemp F, Kolb B, Kovalchuk O. Sex-specific radiation-induced
microRNAome responses in the hippocampus, cerebellum and frontal cortex
in a mouse model. Mutat Res. 2011; 722(2):114-8.
50.
Dickey JS, Zemp FJ, Martin OA, Kovalchuk O. The role of miRNA in the
direct and indirect effects of ionizing radiation. Radiat Environ Biophys.
2011; 50(4):491-9.
51.
Kraemer A, Anastasov N, Angermeier M, Winkler K, Atkinson MJ, Moertl
S. MicroRNA-mediated processes are essential for the cellular radiation
response. Radiat Res. 2011; 176(5):575-86.
52.
Surova O, Akbar NS, Zhivotovsky B. Knock-down of core proteins regulating
microRNA biogenesis has no effect on sensitivity of lung cancer cells to
ionizing radiation. PLoS One. 2012; 7(3):e33134.
53.
Francia S, Michelini F, Saxena A, Tang D, de Hoon M, Anelli V, et al. Site-
specific DICER and DROSHA RNA products control the DNA-damage
response. Nature. 2012; 488(7410):231-5.
54.
Landau DA, Slack FJ. MicroRNAs in mutagenesis, genomic instability, and
DNA repair. Semin Oncol. 2011; 38(6):743-51.
55.
Hu H, Gatti RA. MicroRNAs: new players in the DNA damage response. J
Mol Cell Biol. 2011; 3(3):151-8.
56.
Lal A, Pan Y, Navarro F, Dykxhoorn DM, Moreau L, Meire E, et al. miR-24-
mediated downregulation of H2AX suppresses DNA repair in terminally
differentiated blood cells. Nat Struct Mol Biol. 2009; 16(5):492-8.
57.
Srivastava N, Manvati S, Srivastava A, Pal R, Kalaiarasan P, Chattopadhyay
S, et al. miR-24-2 controls H2AFX expression regardless of gene copy
number alteration and induces apoptosis by targeting antiapoptotic gene
BCL-2: a potential for therapeutic intervention. Breast Cancer Res. 2011;
13(2):R39.
58.
Hu H, Du L, Nagabayashi G, Seeger RC, Gatti RA. ATM is down-regulated
by N-Myc-regulated microRNA-421. Proc Natl Acad Sci U S A. 2010;
107(4):1506-11.
59. Yan D, Ng WL, Zhang X, Wang P, Zhang Z, Mo YY, et al. Targeting DNA-
PKcs and ATM with miR-101 sensitizes tumors to radiation. PLoS One.
2010; 5(7):e11397.
60. Chen S, Wang H, Ng WL, Curran WJ, Wang Y. Radiosensitizing effects of
ectopic miR-101 on non-small-cell lung cancer cells depend on the endogenous
miR-101 level. Int J Radiat Oncol Biol Phys. 2011; 81(5):1524-9.
61. CrosbyME, Kulshreshtha R, IvanM, Glazer PM. MicroRNA regulation of DNA
repair gene expression in hypoxic stress. Cancer Res. 2009; 69(3):1221-9.
62. Arai N, Kagawa W, Saito K, Shingu Y, Mikawa T, Kurumizaka H, et al. Vital
roles of the second DNA-binding site of Rad52 protein in yeast homologous
recombination. J Biol Chem. 2011; 286(20):17607-17.
63.
Hermeking H. MicroRNAs in the p53 network: micromanagement of tumour
suppression. Nat Rev Cancer. 2012; 12(9):613-26.
64.
Medema RH, Mac
ů
rek L. Checkpoint control and cancer. Oncogene. 2012;
31(21):2601-13.
65.
Mansour WY, Bogdanova NV, Kasten-Pisula U, Rieckmann T, Köcher S,
Borgmann K, et al. Aberrant overexpression of miR-421 downregulates
ATM and leads to a pronounced DSB repair defect and clinical
hypersensitivity in SKX squamous cell carcinoma. Radiother Oncol. 2013;
106(1):147-54.
66.
Lee KM, Choi EJ, Kim IA. microRNA-7 increases radiosensitivity of human
cancer cells with activated EGFR-associated signaling. Radiother Oncol.
2011; 101(1):171-6.
67.
Zhang C, Kang C, Wang P, Cao Y, Lv Z, Yu S, et al. MicroRNA-221 and -222
regulate radiation sensitivity by targeting the PTEN pathway. Int J Radiat
Oncol Biol Phys. 2011; 80(1):240-8.
68. Wang Y, Scheiber MN, Neumann C, Calin GA, Zhou D. MicroRNA regulation
of ionizing radiation-induced premature senescence. Int J Radiat Oncol Biol
Phys. 2011; 81(3):839-48.
69. Oh JS, Kim JJ, Byun JY, Kim IA. Lin28-let7 modulates radiosensitivity of
human cancer cells with activation of K-Ras. Int J Radiat Oncol Biol Phys.
2010; 76(1):5-8.