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2017; 63(6):477-480

C

onclusion

Bone and soft tissue tumors of the limbs are diseases with

very variable presentation (histology, stage, volume of

disease and location). Surgery is the treatment of choice

and, because of the highly variable locations, it may not

be feasible in many cases or it may be performed with

minimally recommendable oncological principles.

The disease is a challenge for treatment and it is

highly unlikely that randomized trials testing radiother-

apy techniques will be performed anywhere in the world.

There will probably never be high quality level 1 evidence

for a decision on the radiotherapy technique and, thus,

other criteria should be used for recommendations.

Conventional technique does not allow the physician

to properly view the region being treated, nor the organs

at risk. It does not allow international and national rec-

ommendations for doses in organs at risk because it is

not possible to assess distribution. It is also subject to

gross target location errors due to rotations of the limb

that will be irradiated, which places the muscle bundle

in an unconventional position. In any service that has the

possibility of guiding the treatment using CT scans, we

strongly recommend that the conventional technique be

definitively abandoned as it has been for many years in

developed countries.

If available, IMRT is superior to the others and po-

tentially has a greater ability to control disease with

lower toxicity. Due to a lack of clinical evidence, the min-

imally recommended radiotherapy technique to preserve

the safety of patients with soft tissue tumors of the limbs

is the conformal one.

C

onflict

of

interest

The authors declare no conflict of interest.

R

eferences

1. Almeida CE, Haddad CK, Ferrigno R. A evolução técnica da radioterapia

externa. In: Sociedade Brasileira de Radioterapia. Radioterapia Baseada em

Evidências. Recomendações da Sociedade Brasileira de Radioterapia. 1. ed.

São Paulo: SBRT; 2010. Chapter 2. p. 21-6.

2.

Robinson MH, Bidmed AM, Harmer CL. Value of conformal planning in the

radiotherapy of soft tissue sarcoma. ClinOncol (RColl Radiol).1992; 4(5):290-3.

3. Verhey LJ. Comparison of three-dimensional conformal radiation therapy

and intensity-modulated radiation therapy systems. Semin Radiat Oncol.

1999; 9(1):78-98.

4.

Patel S, DeLaney TF. Advanced-technology radiation therapy for bone

sarcomas. Cancer Control. 2008; 15(1):21-37.

5.

DeLaney TF, Trofimov AV, Engelsman M, Suit HD. Advanced-technology

radiation therapy in the management of bone and soft tissue sarcomas.

Cancer Control. 2005; 12(1):27-35.

6.

Stewart AJ, Lee YK, Saran FH. Comparison of conventional radiotherapy and

intensity-modulated radiotherapy for post-operative radiotherapy for primary

extremity soft tissue sarcoma. Radiother Oncol. 2009; 93(1):125-30.

7.

Hua C, Gray JM, Merchant TE, Kun LE, Krasin MJ. Treatment planning and

delivery of external beam radiotherapy for pediatric sarcoma. Int J Radiat

Oncol Biol Phys. 2008; 70(5):1598-606.

8. Chan MF, Chui CS, Schupak K, Amols H, Burman C, Ling CC. The treatment

of large extraskeletal chondrosarcoma of the leg: comparison of IMRT and

conformal radiotherapy techniques. J Appl Clin Med Phys. 2001; 2(1):3-8.

9. Griffin AM, Euler CI, Sharpe MB, Ferguson PC, Wunder JS, Bell RS, et al.

Radiation planning comparison for superficial tissue avoidance in

radiotherapy for soft tissue sarcoma of the lower extremity. Int J Radiat

Oncol Biol Phys. 2007; 67(3):847-56.

10.

Ś

l

adowska A, Hetnał M, Dymek P, Kabat D, Kisielewicz K, Wawrzak M, et al.

Application of IMRT in adjuvant treatment of soft tissue sarcomas of the

thigh – Preliminary results. Rep Pract Oncol Radiother. 2011; 16(3):110-4.

11. Alektiar KM, Brennan MF, Healey JH, Singer S. Impact of intensity-

modutaded radiation therapy on local control in primary soft-tissue sarcoma

of the extremity. J Clin Oncol. 2008; 26(20):2440-4.

12.

Folkert MR, Singer S, Brennan MF, Kuk D, Qin LX, Kobayashi WK, et al.

Comparison of local recurrence with conventional and intensity-modulated

radiation therapy for primary soft-tissue sarcomas of the extremity. J Clin

Oncol. 2014; 32(29):3236-42.

13. O’Sullivan B, Griffin AM, Dickie CI, Sharpe MB, Chung PW, Catton CN, et

al. Phase 2 study of preoperative image-guided intensity-modulated radiation

therapy to reduce wound and combined modality morbidities in lower

extremity soft tissue sarcoma. Cancer. 2013; 119(10):1878-84.

14.

Lin C, Donaldson SS, Meza JL, Anderson JR, Lyden ER, Brown CK, et al.

Effect of radiotherapy techniques (IMRT vs. 3D-CRT) on outcome in patients

with intermediate-risk rhabdomyosarcoma enrolled in COG D9803—A

report from the Children’s Oncology Group. Int J Radiat Oncol Biol Phys.

2012; 82(5):1764-70.